|Organization:||Gestion Univalor, Limited Partnership, Quebec, CA|
|I.P. Brief:||Porous and Utra-Porous polymer substrates are fabricated by assembling polyelectrolyte and protein layers onto the internal surface of porous co-continuous polymer blend. The blend template is then removed through selective solvent extraction.|
|Summary of I.P.:||Porous polymer materials with interconnected porosity are receiving great attention recently due to their wide range of potential applications and the preparation challenges they pose. The potential applications range from the biomedical and pharmaceutical fields (tissue engineering and drug delivery) to chromatographic materials to catalysis of chemical and biochemical reactions. In addition, new challenges have been raised to produce materials having great surface to volume ratios, and internal volume to external volume ratios.
One of the main problems related to existing and under development processes is to encapsulate materials with a shield or other material.
The process proposed has many applications from life science to chemical engineering.|
|Patent:||US Provisional 60/735,890, Ultra-porous polymer nanosheath networks and method of making.|
|Keywords:||Ulta-porous, Porous, Polymer, Networks, Nanosheath, Replication, Polyelectrolyte, self-assembled layers, LBL Deposition.|
|Specific Market:||Global Chemical market for (Catalysts, biocatalysts, drug delivery, tissue engineering)|
|Market Size:||Each of the markets addressed by the technology exceeds billion of dollars, but is already addresses by current technologies. Niche applications of such a process will contribute the growth of this market.|
|State of the Art:||Different techniques to fabricate interconnected porous polymer substrates exist: fiber bonding, solvent casting, gas foaming, phase separation and emulsion. However, every one of these approaches suffers from severe limitations including: low levels of interconnectivity; low void volume; poor control of pore size and distribution and difficulties in obtaining reproducible porosities.|
|Figures of Merit:||he capability of controlling the porosity of material created since one can imagine creating a material with no porosity at its outside surface, and having different compartments designed with different void volumes. In addition, the process allows the fabrication of structures having void fractions up to 99.6%.|
|Tech. Obstacles:||- The main technical challenge is to find for each application the materials compatibles with the replication concept as well as adapted to the usage of the final product;
-- Controlling the structure so that ultra-porous materials produced maintain mechanical properties;
-- Being able to mass produce materials depending on the application.
|Market Obstacles:||- Identifying the application capturing the highest added-value of controlling porosity anywhere in a material, and producing material with up to 99,6% of void fraction;|
|Patent Landscape:||60/735,890,Ultra-porous polymer nanosheath networks and method of making
WO 2004/087797, Microporous articles comprising biodegradable medical polymers, method of preparation thereof and method of use thereof
|Publications:||1: Sarazin P, Roy X, Favis BD.
Controlled preparation and properties of porous poly(L-lactide) obtained from a co-continuous blend of two biodegradable polymers.
Biomaterials. 2004 Dec;25(28):5965-78.
2: Sarazin P, Favis BD.
Morphology control in co-continuous poly(L-lactide)/polystyrene blends: a route towards highly structured and interconnected porosity in poly(L-lactide) materials.
Biomacromolecules. 2003 Nov-Dec;4(6):1669-79.
3: Sarazin, P., Favis, B.D.,
Preparation and Properties of Porous Poly(L-Lactide) obtained from a Co-Continuous Blend of Two Biodegradable Polymers.
Biomaterials 2004, 25, 5965.
4: Yuan Z, Favis BD.
Macroporous poly(L-lactide) of controlled pore size derived from the annealing
of co-continuous polystyrene/poly(L-lactide) blends.
Biomaterials. 2004 May;25(11):2161-70.
|Research Team:||Dr Basil Favis has been involved in more than 150 scientific publications related to multiphase polymers (he has been cited more than 750 times during the last five years). He is professor in chemical engineering interested in characterization and production of nano-composite polymers oomposites. He is also an entrepreneur|