Copper-Dependent Non-Traditional Pro-Inflammatory Cytokine Export and Methods
|Organization:||Maine Medical Center Research Institute, Maine Medical Center Research Institute, US|
|I.P. Brief:||The inventors have discovered that non-traditional export of certain pro-inflammatory cytokines lacking a signal sequence from a cell can be inhibited by copper chelation. |
|Summary of I.P.:||Copper chelation inhibits neointima formation, macrophage infiltration and associated inflammation, cell proliferation, secretion of extracellular matrix, intimal thickening, adventitial angiogenesis, restenosis, and vascular vessel injury in general. This invention describes a unique way of managing Interleukin-1 and FGF activity at the cellular level, which leads to the opportunity for a variety of therapeutic benefit. In vivo data has been generated and is available under a confidentiality agreement.
Advantages: This invention provides novel methods for preventing and treating various diseases, including Alzheimers, Lupus, and Arthritis. There is a striking similarity to the structure of FGF and therefore leads to the hypothesis that these may be treated like a vascular disease. There are complimentary patents available as well.
|Keywords:||FGF, IL-1, lupus, alzheimers, arthritis|
|Primary Industry:||Pharma & Biotech|
|Specific Market:||Alzheimers, Lupus, Arthritis|
|Market Size:||In excess of $1 billion|
|State of the Art:||There are various strategies for each indication.|
|Figures of Merit:||This is part of a broad family of IP that can be used to address these indications. |
|Tech. Obstacles:||None known at this time.|
|Market Obstacles:||Need to move from mouse models to larger animal models to validate the concept.|
|Publications:||Tarantini, F., Micucci, I., Bellum, S., Landriscina, M., Garfinkel, S., Prudovsky, I., and T. Maciag. The Precursor But Not the Mature Form of IL1• Blocks the Release of FGF1 in Response to Heat Shock, J. Biol. Chem., Rapid Commun., 2001; 276:5147-5151.
Prudovsky, I., Mandinova, A., Soldi, R., Bagalá, C., Graziani, I., Landriscina, M., Tarantini, F., Duarte, M., Bellum, S., Doherty, H. and Maciag, T. The Non-Classical Export Routes: IL1 and FGF1 Point the Way. J. Cell Sci. 2003; 118:4871-81.
|Research Team:||Igor Prudovsky|