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(joint with Nanotech 2006)
Copper-Dependent Non-Traditional Pro-Inflammatory Cytokine Export and Methods
| Organization: | Maine Medical Center Research Institute, Maine Medical Center Research Institute, US |
| I.P. Brief: | The inventors have discovered that non-traditional export of certain pro-inflammatory cytokines lacking a signal sequence from a cell can be inhibited by copper chelation. |
| Summary of I.P.: | Copper chelation inhibits neointima formation, macrophage infiltration and associated inflammation, cell proliferation, secretion of extracellular matrix, intimal thickening, adventitial angiogenesis, restenosis, and vascular vessel injury in general. This invention describes a unique way of managing Interleukin-1 and FGF activity at the cellular level, which leads to the opportunity for a variety of therapeutic benefit. In vivo data has been generated and is available under a confidentiality agreement. Advantages: This invention provides novel methods for preventing and treating various diseases, including Alzheimers, Lupus, and Arthritis. There is a striking similarity to the structure of FGF and therefore leads to the hypothesis that these may be treated like a vascular disease. There are complimentary patents available as well. |
| Patent: | Patents pending |
| Keywords: | FGF, IL-1, lupus, alzheimers, arthritis |
| Primary Industry: | Pharma & Biotech |
| Specific Market: | Alzheimers, Lupus, Arthritis |
| Market Size: | In excess of $1 billion |
| State of the Art: | There are various strategies for each indication. |
| Figures of Merit: | This is part of a broad family of IP that can be used to address these indications. |
| Tech. Obstacles: | None known at this time. |
| Market Obstacles: | Need to move from mouse models to larger animal models to validate the concept. |
| Publications: | Tarantini, F., Micucci, I., Bellum, S., Landriscina, M., Garfinkel, S., Prudovsky, I., and T. Maciag. The Precursor But Not the Mature Form of IL1• Blocks the Release of FGF1 in Response to Heat Shock, J. Biol. Chem., Rapid Commun., 2001; 276:5147-5151. Prudovsky, I., Mandinova, A., Soldi, R., Bagalá, C., Graziani, I., Landriscina, M., Tarantini, F., Duarte, M., Bellum, S., Doherty, H. and Maciag, T. The Non-Classical Export Routes: IL1 and FGF1 Point the Way. J. Cell Sci. 2003; 118:4871-81. |
| Research Team: | Igor Prudovsky |
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