Sapient Discovery, LLC.

Location:CA, US
Speaker:Kal Ramnarayan
Title:President and Chief Scientific Officer
Primary Industry:Pharma & Biotech
Executive Summary:Advances in genome sequencing and disease processes have resulted in a glut of potential new drug targets. While high throughput screening (HTS) methods have played some role in easing this bottleneck, HTS is very expensive, has limited scalability, and samples a very small portion of “structural space” -- typically limited to screening the already “over-mined” in-house libraries of drug companies. HTS poses a formidable economic challenge to many smaller companies. Larger pharmaceutical companies, while able to afford high throughput screening, have throughput and queuing issues, causing delays or exclusion of promising targets screening. Sapient Discovery offers an accelerated, powerful, and proven structure-based approach to accelerating lead discovery and optimization for protein drug targets, termed Genes-to-Leads®. Genes-to-Leads® combines four technologies: X-ray crystallography, Augmented Homology Modeling, StructureBank™ and DynaPharm™ based virtual screening, for rapidly identifying novel and selective small-molecule inhibitor/antagonist leads with 100 fold increase in drug screening efficiency. Genes-to-Leads® is offered as a stand-alone business solution for smaller biotech or pharma companies. And integration of the proprietary. The technology has delivered novel, selective, multi-scaffold, lead molecules for more than 18 targets.
Venture is:Seed Level


Corporate Presentations:

  • Air Products
  • BASF
  • Eastman Kodak Company
  • Genzyme
  • Goodrich
  • Hewlett-Packard
  • Honda
  • Medtronic
  • Merck
  • Sanyo

Reserved Presentations:

  • ExxonMobil
  • IBM

Partnering Events:
(full access included)

Platinum Sponsor

University of Hawaii

Press Sponsor

Business Wire

Commercialization Partner



Invest Australia AzTE Technology Enterprises

Media Sponsors

(joint with Nanotech 2007) Nature
Red Herring

Supporting Organizations

Boston University
Midwest Research University Network


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