Aphios Corporation

Location:MA, US
Speaker:Trevor Castor
Primary Industry:Pharma & Biotech
Executive Summary:Lack of sufficient oral bioavailability hinders development of potential anticancer drugs. By enhancing the oral bioavailability of such compounds, therapeutically beneficial products could be developed, especially where long-term exposure is needed for maximum therapeutic effect. If successful, these techniques can be applied to a number of existing drugs as well as to several potential drug candidates of interest to the pharmaceutical industry and the National Cancer Institute. Oral formulation will reduce or eliminate the need for protracted intravenous drug delivery. This will not only benefit patients in terms of convenience, but will also reduce the overall costs of treatment by reducing ohospitalization and visits to clinics, and improve patients’ quality-of-life. Based on preliminary data and scientific rationalization, we hypothesized and then demonstrated that encapsulated anticancer drug nanoparticles in biodegradable polymer nanospheres will allow transport to the stomach and enhance bioavailability. We also hypothesized and demonstrated that both drug nanoparticles and the encapsulation of these particles in biodegradable polymer nanospheres can be formed utilizing supercritical fluid technologies. This approach has averted the use of conventional organic phase techniques that utilize a number of processing steps, large quantities of organic solvents, and are very time consuming, costly and inefficient.
Venture is:A-Round


Corporate Symposium

Harvard OTD
Partner Sponsor

2008 Corporate Presentations

Air Products
  • BASF
  • Genzyme
  • Lockheed Martin
  • Sanyo

Event Sponsors

Jackson Walker

Collocated Events

June 1-5, 2008
Nanotech 2008
Clean Technology 2008
BioNano 2008

Press Sponsor

Business Wire

Commercialization Partner


Media Sponsors

(joint with Nanotech 2008) Nature
Red Herring

Supporting Organizations

Boston University
Midwest Research University Network


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