Arrogene Inc

Location:California, US
Speaker:Dr. Julia Ljubimova
Title:Company Founder
Primary Industry:Pharma & Biotech
Executive Summary:A nanobiopolymer for drug delivery based on polymalic acid (PMLA) was invented by scientists from Arrogene Inc. and Cedars-Sinai Medical Center, Los Angeles. A significant feature of novel drug, based on this universal nanoplatform, is its ability to target multimeric tumor-associated proteins with one drug, a capability that other existing agents do not have. We have shown a significant anti-tumor and anti-angiogenic activity of this drug, Polycefin. Two antisense oligonucleotide inhibitors of synthesis of chains of laminin-411 a tumor vascular wall protein, were delivered simultaneously to brain tumor cells using antibody attached to the PMLA-based drug delivery molecule, Polycefin. Evidence is presented that the delivery system passes through the blood-brain and blood-tumor barriers. The inhibitors targeted α4 and β1 chains of laminin-411 and inhibited their synthesis in vitro and in vivo. Treatment of glioma-bearing animals with Polycefin significantly diminished tumor vascularity and significantly increased animal survival (p<0.004). This nanoscale drug delivery system, Polycefin, proved a suitable device for the targeted in vivo delivery of antisense oligonucleotides/siRNA/chemotherapeutical drugs/monoclonal antibodies specifically to the tumor cells.
Venture is:Seed Level

HIGHLIGHTS

Merck
Corporate Symposium

Harvard OTD
Partner Sponsor

2008 Corporate Presentations

Air Products
Boeing
BP
Cabot
Honda
Kodak
Medtronic
Merck
  • BASF
  • Genzyme
  • Lockheed Martin
  • Sanyo

Event Sponsors

Univalor
AzTE
Jackson Walker

Collocated Events

June 1-5, 2008
Nanotech 2008
Clean Technology 2008
BioNano 2008

Press Sponsor

Business Wire

Commercialization Partner

BusinessWeek

Media Sponsors

(joint with Nanotech 2008) Nature
Science
Red Herring

Supporting Organizations

Boston University
Midwest Research University Network
piribo

 

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