C. Murphy, H. Jankevics-Jones
Malvern Instruments Ltd, United Kingdom
pp. 21 - 24
Keywords: nanoparticle, inorganic, liposomes, biological, gold, resonant mass measurement, dynamic light scattering, nanoparticle tracking analysis
Nanoparticle controlled drug delivery technology represents a rapidly advancing arena in medical treatment. These delivery systems offer numerous advances compared to conventional dosage forms which include improved efficacy, reduced toxicity and improved patient compliance and convenience. Nanoparticles used in this area can come in a variety of guises which include, organic, inorganic, liposomes and biological. These nanoparticles can be used to store a small molecule drug either internally or on their periphery to the targeted site. One of the characterisation challenges associated with these delivery vehicles is understanding how much drug is loaded within or on the nanoparticle. In this research, we look at how three different techniques which are resonant mass measurement, dynamic light scattering and nanoparticle tracking analysis can be used to characterise a variety nanoparticle drug delivery vehicles. In particular we are able to monitor the size and charge variations on the nanoparticles along with measuring the amount of drug loaded, which are shown to impact greatly on both their stability and efficacy.