National University of Singapore, Singapore
pp. 567 - 570
Keywords: Endothelial, epithelial, nanotoxicity
Nanoparticles regardless as subjects of nanotoxicity or nanomedicine studies will inevitably interact with endothelial and epithelial cells. In the case of nanomedicine, while these cells are usually not the intended target, nanoparticles first interact with them. It is therefore important to understand the effects of these nanoparticles on these cells. Using generic and commonly found non-decorated nanomaterials like TiO2, silica, silver, hydroxyapatite nanoparticles, we discovered interesting new effects and solved their mechanisms. We discovered that nanoparticles can cause endothelial leakiness (NanoEL) in vitro and in vivo by finding its way into the spaces (adherens junctions) between endothelial cells, disrupts the homophillic interactions of VE-Cadherin and trigger the signaling pathway that leads to micron sized gaps between endothelial cells (Setyawati, Nature Comms 2013). We also discovered that nanoparticles can inhibit cell migration by targeting and disrupting microtubules. This increases focal adhesion at the interface of surfaces and transmit to increased cell traction (Tay, Nano Letts 2014). This talk will also discuss about implications of these novel observations to nanotoxicity and nanomedicine.