Advanced Materials: TechConnect Briefs 2015Advanced Materials TechConnect Briefs 2015

Nanoparticle Synthesis & Applications Chapter 5

Core-shell Silica-coated Iron Oxide Nanoparticles for Magnetic Hyperthermia

Y. Iqbal, H. Bae, S. Hong, I. Rhee
Kyungpook National University, Korea

pp. 246 - 249

Keywords: silica-coated iron oxide nanoparticles, magnetic hyperthermia, specific absorption rate (SAR)

We report the synthesis and characterization of silica-coated iron oxide nanoparticles with a core-shell structure for magnetic hyperthermia. The nanoparticles of silica-coated iron oxide were synthesized using the reverse micelle method. The coating of the silica was performed simultaneously with the synthesis of the nanoparticles. The nanoparticles were characterized by various analytical tools. X-ray diffraction (XRD) confirmed a cubic spinel structure. Transmission electron microscopy (TEM) results showed near-mono-disperse spherical core-shell structures with nanoparticles having an average diameter of 17 nm. The binding of the silica on the surface of the iron oxide nanoparticles was revealed by Fourier transform infrared spectrometry (FTIR). The as-synthesized silica-coated iron oxide nanoparticles exhibited superparamagetic properties with a saturation magnetization of 48.8 emu/g measured by a vibrating sample magnetometer (VSM). Moreover, the inductive heating ability of the nanoparticles dispersed in water with a concentration of 20 mg/ml was investigated in a 1.03-kA/m, 260-kHz alternating magnetic field. The results revealed a heat release of up to 139 W per one gram of iron, demonstrating the potential application of the nanoparticles in magnetic hyperthermia.