Texas A&M International University, United States
pp. 440 - 443
Keywords: nanoparticles, magnetic hyperthermia
We propose to develop a novel combination therapy for prostate/breast treatment by combining two treatment modalities (hyperthermia therapy and chemotherapy) into one using MCaP nanoparticles (NP) system. Our proposed MCaP NPs possess unique properties, including: 1) superparamagnetism: paramagnetic particles can generate heat (hyperthermia) that can kill cancer cells when a remote, medium, external inducting alternated magnetic field (AMF) is applied; 2) high surface area for drug loading and release; and 3) abundant surface functional groups for attachment of targeting/imaging moieties. In this study by using magnetic induction heating to characterize the properties of newly-formulated iron-doped CaP paramagnetic (Fe-n-CaP) based nanoparticles (NPs) in vitro. Particularly, our newly formulated nanoparticle Fe-n-CaP with dual therapy functions for cancer treatment can reach the required therapy temperature. The experiments show that under the selected field parameters, sufficient energy deposition is achieved which leads to a substantial temperature increase within a short-time frame. And also inductive heating experiments on Fe-n-CaP water suspension injected into muscle tissue was successes at magnetic field with current 25A, frequency 330 kHz. There are additional studies are underway: reduce the size of the nanoparticle size as possible; and control the drug release with the temperature change.