H.S. Sharma, D.F. Muresanu, L. Feng, J.V. Lafuente, R. Patnaik, Z.R. Tian, A. Ozikzilcik, H. Mössler, A. Sharma
Uppsala University, Sweden
pp. 41 - 44
Keywords: nanowired erebrolysin, mesenchymal stem cell, neuroprotection, concussive head injury
Concussive head injury (CHI) could lead to either instant death or lifetime disabilities. Our soldiers are highly vulnerable to CHI during combat operations. Thus, to treat these soldiers effectively novel strategies using combination therapy is needed. Since stem cell therapy enhances neurorepair in brain or spinal cord injuries, this is quite likely that this may be effective in CHI as well. However, this is still unclear whether CHI occurring at high environmental temperature could adversely affect the outcome with regard to brain pathology or sensory motor disturbances. Since our soldiers are often engaged in combat operations in desert environments under high heat conditions, this is likely that their outcome following CHI require special treatment using combination therapy. In this investigation we used nanowired delivery of mesenchymal stem cells (MSCs) intravenously following CHI and also added a known neuroprotective multimodal drug Cerebrolsyin with or without nanowired delivery to see whether a synergistic better effects of this combination can result in good neurorepair following CHI at high environmental heat situations. Our results showed that a combination of nanowire stem cells and cerebrolysin is the most effective in reducing brain pathology following CHI at hot environment, not reported earlier.