Biotech, Biomaterials and Biomedical: TechConnect Briefs 2015Biotech, Biomaterials and Biomedical TechConnect Briefs 2015

Sensors, Diagnostics & Imaging Chapter 3

High-sensitive, direct and label-free detection technique of nanotoxic material using QCM

K. Jang, J. You, C. Park, J. Park, S. Na
Korea University, Korea

pp. 180 - 182

Keywords: quartz crystal microbalance, nanotoxic material, resonance sensor

For the several decades, various nanomaterials are broadly used in industrial fields, research areas and commercialized products. Among many nanomaterials, silver ion, carbon nanotube, ZnO, and mercury ion etc are of the widely used nanomaterial in real life. However, high toxicity of those materials has been reported and the detection method is required for human health and environment. In present study, high-sensitive, label-free detection method of nanotoxic materials are described. We have developed an sensitive and selective quart crystal microbalance (QCM) based sensor for detection of nanotoxic material by using frequency shift. In this study, we propose the sensitive in situ detection of nanotoxic material by using QCM functionalized with a specific DNA for a target material. It also allows the detection of target material rapidly in real time. In contrast to the conventional methods, this method is label-free and senitive, capable of direct rapid detection and real-time monitoring. The results suggest that QCM-based detection opens a new avenue for the development of a practical water-testing sensor.