C.E. Rapier, E. Chen, W.F. Liu, A.P. Lee
University of California, Irvine, United States
pp. 246 - 248
Keywords: PLGA, stent, particles, microfluidics, anti-inflammatory, immunomodulatory
Biodegradable/bioabsorbable materials are a relatively new movement in the implantable medical device field. Despite the promise of non-permanent implants, bioabsorbable materials can induce a localized inflammatory immune response. To overcome this limitation, we are combining the bioabsorbable property of PLGA and the anti-inflammatory property of an immunomodulatory protein. We are using a microfluidic system designed to conjugate functionalized proteins to PLGA, forming protein-polymer hybrid particles. In the future, we hope to create vascular stents with this anti-inflammatory PLGA material which would provide a non-permanent, biodegradable alternative to conventional stent materials.