Biotech, Biomaterials and Biomedical: TechConnect Briefs 2015Biotech, Biomaterials and Biomedical TechConnect Briefs 2015

Materials for Personal/Home Care & Cosmetics Chapter 6

The use of Ag5IO6 as an antimicrobial agent in wound dressing against microbial biofilms

V. Incani, A. Omar, G. Prosperi-Porta, P. Nadworny
Innovotech Inc, Canada

pp. 289 - 292

Keywords: anti-biofilm, silver periodate, infection, nanostructure, medical device, anti-adherence

This work explores the unique antibiofilm activity of pentasilver hexaoxoiodate (Ag5IO6). Impregnated wound dressings with Ag5IO6 were designed and their antibiofilm activity was compared with various commercially available silver and non silver-containing dressings. Ag5IO6-wound dressings demonstrate that Ag5IO6 have superior activity compared to a number of antimicrobials, with broad-spectrum efficacy that includes long-term prevention of microbial adherence, rapid kill of planktonic micro-organisms, and the ability to disrupt and eliminate mature biofilms. Thus, Ag5IO6 may be a valuable antimicrobial agent for use in a number of medical device applications, including wound dressings, various catheters or implants.