B.K. Lee, J.S. Kwon, J.H. Park, D.Y. Kwon, J.H. Kim, S.H. Oh, M.S. Kim
Ajou University, Korea
pp. 327 - 330
Keywords: thermogelling materials, phase transition, diblock copolymer, in vivo
To investigate thermogelling behavior, in this study, methoxy polyethylene glycol-b-[poly(ε-caprolactone)-ran-poly(6-chloride-ε-caprolactone) (PCL-ran-PfCL)] (PCL-Cl) diblock copolymers were designed such that the PfCL content in the PCL segment was varied. The PCL-Cl diblock copolymers were derivatized by introducing a pendant amine group at the PfCL segment (PCL-NH2). We confirmed that that PCL-NH2 diblock copolymer solution may potentially be used as thermogelling materials into the body in a minimally invasive manner.