Biotech, Biomaterials and Biomedical: TechConnect Briefs 2015Biotech, Biomaterials and Biomedical TechConnect Briefs 2015

Soft Matter & Colloids Chapter 7

Preparation of ion group functionalized diblock copolymers and examination of their thermogelling properties

B.K. Lee, J.S. Kwon, J.H. Park, D.Y. Kwon, J.H. Kim, S.H. Oh, M.S. Kim
Ajou University, Korea

pp. 327 - 330

Keywords: thermogelling materials, phase transition, diblock copolymer, in vivo

To investigate thermogelling behavior, in this study, methoxy polyethylene glycol-b-[poly(ε-caprolactone)-ran-poly(6-chloride-ε-caprolactone) (PCL-ran-PfCL)] (PCL-Cl) diblock copolymers were designed such that the PfCL content in the PCL segment was varied. The PCL-Cl diblock copolymers were derivatized by introducing a pendant amine group at the PfCL segment (PCL-NH2). We confirmed that that PCL-NH2 diblock copolymer solution may potentially be used as thermogelling materials into the body in a minimally invasive manner.