E.T. Chen, J. Thornton, C. Mulchi Jr.
Advanced Biomimetic Sensors, Inc., United States
pp. 200 - 203
Keywords: nanobiomimetic neuronal memcapacitor, circadian rhythm, reentrant-recursive, spatial-temporal orientation, 3D energy-sensory reentrant map, dysfunction of memory
Circadian Rhythm (CRR) dysfunction of Alzheimer’s has been recognized as an early sign in correlation with -Amyloid (A) damage late happened in the brain. We report a nanostructured memcapacitor memory device for detecting an energy change in aWHr level based on a double step chronopotentiometry method, a cyclic voltammetry (CV) method with sensory-energy maps having “sensory biomarks” over 0.25-333 Hz, and the results were compared under the conditions of free of tracers and antibodies. Device 1 made with a biomimetic acetylcholinesterase (ACHE) active membrane discharges normal CRR based on the reentrant circuitry with High Frequency Oscillation (HFO) and is sensitive to low A concentration damage based on Spatial-Temporal orientations. Device 2 made with a “mutated ACHE” membrane has dysfunctional CRR and was damaged with “epilepsy” due to Pathological High Frequency Oscillation (pHFO) and large areas of A depositions at high concentration. Sensor 2 predicted an early sign of “epilepsy” episode based on a pHFO was observed and late was confirmed with circuitry surface conformation change and reentrant change at 38 µM A, especially at slow-wave sleeping. The HFO and pHFO close to the origin in the maps is a remarkable event.