S.E. Gilliland III, E.E. Carpenter, M.D. Shultz
McGuire VA Medical Center, United States
pp. 306 - 309
Keywords: hyperthermia, iron oxide, benzyl alcohol, seed growth, nanoparticles, surface functionalization
Iron oxide nanoparticles have received sustained interest for biomedical applications as synthetic approaches are continually developed for precise control of nanoparticle properties. This work presents an investigation of parameters in the benzyl alcohol synthesis of iron oxide nanoparticles. A modified seed growth method was designed for obtaining optimal nanoparticle properties for magnetic fluid hyperthermia. With a one or two addition process, iron oxide nanoparticles were produced with crystallite sizes ranging from 5-20 nm using only benzyl alcohol and iron precursor. The effects of reaction environment, temperature, concentration, and modified seed growth parameters were investigated to obtain precise control over nanoparticle properties affecting radiofrequency heat generation. Two different surface functionalization of the as synthesized particles were compared for stability and cellular uptake efficiency. The benzyl alcohol modified seed growth method offers great potential for synthesizing iron oxide nanoparticles for radiofrequency hyperthermia.