Biotech, Biomaterials and Biomedical: TechConnect Briefs 2015Biotech, Biomaterials and Biomedical TechConnect Briefs 2015

Materials for Drug & Gene Delivery Chapter 1

Thermally responsive lipid coated superparamagnetic nanoparticles for frequency triggered drug delivery

Y. Patil-Sen, M. Eizadi Sharifabad, T. Mercer, G. Bond, T. Sen
University of Central Lancashire, United Kingdom

pp. 21 - 24

Keywords: superparamagnetic nanoparticles, lipids, drug delivery, magnetic hyperthermia

In this abstract, we report a series of novel thermally responsive lipid coated core-shell mesoporous silica-superparamagnetic iron oxide nanoparticles as drug delivery vehicles for potential use for cancer therapy under magnetic hyperthermia. Hydrophilic anticancer drug "Doxorubicin" was loaded inside mesoporous silica which was then encapsulated in thermally responsive phospholipids. The novel materials have been tested as drug delivery vehicle both under thermal incubation and alternating magnetic field (magnetic hyperthermia) at 37 degree Celsius. It has been proven first time that drug can be released under a controlled condition when using the AC magnetic field in vitro. Initial results for anticancer efficiency and toxicity of nano-particles against MCF breast-cancer cell line will be discussed.