Y. Patil-Sen, M. Eizadi Sharifabad, T. Mercer, G. Bond, T. Sen
University of Central Lancashire, United Kingdom
pp. 21 - 24
Keywords: superparamagnetic nanoparticles, lipids, drug delivery, magnetic hyperthermia
In this abstract, we report a series of novel thermally responsive lipid coated core-shell mesoporous silica-superparamagnetic iron oxide nanoparticles as drug delivery vehicles for potential use for cancer therapy under magnetic hyperthermia. Hydrophilic anticancer drug "Doxorubicin" was loaded inside mesoporous silica which was then encapsulated in thermally responsive phospholipids. The novel materials have been tested as drug delivery vehicle both under thermal incubation and alternating magnetic field (magnetic hyperthermia) at 37 degree Celsius. It has been proven first time that drug can be released under a controlled condition when using the AC magnetic field in vitro. Initial results for anticancer efficiency and toxicity of nano-particles against MCF breast-cancer cell line will be discussed.