L. Li, Z. Gu, W.Y. Gu, J. Liu, Z.P. Xu
Australian Institute for Bioengineering and Nanotechnology, Australia
pp. 17 - 20
Keywords: LDH nanocomposities, drug delivery, cancer treatment
Target-specific delivery and sustained release of anticancer agents and siRNA has attracted considerable research interest in cancer chemotherapy. Recently, we have developed layered double hydroxide (LDH) vector to efficiently deliver drug and siRNA into the cancer cells to inhibit the cancer cell growth. However, LDH nanoparticles easily form a random agglomeration in phosphate buffer solution (PBS) and cell culture medium. To circumvent the aggregation of layered double hydroxide nanoparticles in medium and targeted delivery of drug/gene, we have designed and synthesized an amine-functionalized SiO2 nanodot-coated LDH nanocomposite (NH2-SiO2@LDH) to deliver MTX, an anticancer drug, into the cancer cells. The cell testing shows NH2-SiO2@MTX-LDH nanocomposites exhibited enhanced suppression of cancer cell growth in a dose-dependent manner, attributed to quick uptake of the nanocomposites. Therefore, monodispersed SiO2@LDH nanohybrids can be an excellent non-viral delivery carrier for drug and gene deivery.